Endocrine Abstracts

Introduction: NICE guidelines recommend additional support is provided to CYP with a high HbA1c. Elective hospital admissions are one option for improving glycaemic control.Aims/objectives: To evaluate the implementation of, and impact on HbA1c of, planned admissions in CYP in our service.Methods: All planned admissions for management of sustained high HbA1c in patients with known ...

Background: Historically, a second LHRH stimulation test has been the gold standard test for the evaluation of biochemical evidence of pubertal suppression in patients with central precocious puberty (CPP) following commencement of GnRH analogue therapy. However, this test is time-consuming, costly, and uncomfortable for patients.Aims/objective: To analyse the validity of the basal LH level as a predictor to the peak LH ...

Introduction: Our current local management guidelines for Graves’ Disease (GD) in children and young people (CYP) do not include routine screening for coeliac disease (CD). However, ad hoc testing of patients in this cohort pointed to a high incidence of positive tissue transglutaminase (TTG) results.Aims/Objectives: 1. To determine the incidence of CD in patients in our service diagnosed with GD. 2. To establish if...

Presentation and investigation: A 10-month-old girl presented with a bluish lump on the left side of her abdomen which was increasing in size. An abdominal mass was palpable on examination. An ultrasound showed a large, partly calcified mass measuring 9×6×9 cm arising from the left adrenal gland. There were also calcified lesions in her liver and lungs suggesting metastsis. MRI confirmed the ultrasound finding plus detected an intraspinal deposit with some cord compr...

Aims: To assess the relationship between thyroid peroxidase (TPO) antibodies and the development of thyroid disorders in children with type 1 diabetes mellitus (T1DM).Method: TPO antibody status and duration of diabetes at diagnosis of thyroid disorder were cross-sectionally examined in all children attending the Oxford T1DM service (n=342, male:female ratio 1:0.8).Results: Twenty patients were identified with thyroid como...

Introduction: Pancreatogenic diabetes (Type 3c diabetes-T3cDM) is rare in children, and frequently underdiagnosed. The prevalence is 5–10% of all adult diabetes cases in the developed world. Over 78% of people with T3cDM have chronic pancreatitis.Case: A 15-year old presented with polyuria, polydipsia, abdominal pain, weight loss (WL) and a three-generational family history of type-1 (T1DM) and type-2 diabetes mellitus (T2DM). Examination revealed m...

Background: There is growing recognition of the importance of sports/exercise in children and young people (CYP) with type 1 diabetes (T1DM) [NICE guidance 1.2.47–1.2.53]. In 2014 our Paediatric Diabetes service set up a Diabetes Sports clinic run by a paediatric diabetologist and dietician and an adult diabetologist. Appointments were offered to families of CYP with T1DM who are ‘elite sportspersons’–performing at competitive levels, or regional/national l...

Objectives: Recently updated NICE guidelines (2015) on coeliac screening for children with Type 1 diabetes mellitus (T1DM) recommend just one initial screen for coeliac disease (CD) at the time of T1DM diagnosis and thereafter only if symptomatic. This is in contrast to the recommendation for on-going annual screening for autoimmune thyroid disease (ATD). Our unit has historically performed annual screening for both ATD and CD. Our study aimed to establish whe...

Introduction: Children with Down syndrome (trisomy-21/T21) are at risk of developing congenital and early (diagnosed ≤1 year) hypothyroidism. Our current monitoring follows the Down Syndrome Medical Interest Group (DSMIG) guidance: performing thyroid function tests (TFT) at birth and 12 months.Aims/objectives: 1) Determine the incidence of congenital/early hypothyroidism in babies with T21 and determine long-term thyroid function outcomes (by age 4...

Background: A 5-month-old girl presented with a history of acute abdominal distension over several weeks. Three weeks previously she had developed pubic hair, and some early breast development. The GP had reassured parents on two occasions that this was normal. On examination she had Tanner breast stage 3 bilaterally, pubic hair stage 3, mild cliteromegaly, and gross abdominal distension.Investigations: An ultrasound scan revealed a massively enlarged ri...